Seattle Seahawks vs Arizona Cardinals – NFL Prediction
Match Preview
Sam Darnold is sidelined with a soft-tissue glute injury, throwing backup Drew Lock right into the spotlight for this Week 2 rivalry game. Can Lock build on his Week 1 performance where he stepped in and hit 16 of 22 passes for 187 yards and a touchdown? Meanwhile, head coach Mike LaFleur is coming off a debut win with Arizona after topping the Chargers 26-14. I expect this NFC West battle to be far more intense than the opening lines indicate.
Seattle Seahawks – Team Analysis
| Date | Stage | Opponent | Score | Result |
|---|---|---|---|---|
| 2026-09-10 | Regular Season | vs New England Patriots | 13-10 | W |
| 2026-08-29 | Pre Season | @ Kansas City Chiefs | 9-9 | L |
| 2026-08-24 | Pre Season | @ Tennessee Titans | 16-19 | L |
| 2026-08-16 | Pre Season | vs Dallas Cowboys | 7-17 | L |
| 2026-02-08 | Post Season | @ New England Patriots | 29-13 | W |
| Stat | Value |
|---|---|
| Avg Points Scored | 14.8 pts/game |
| Avg Points Conceded | 13.6 pts/game |
| Current Form | WLLLW |
| Total Yards | 312.6 yards/game |
| Passing Yards | 204.2 yards/game |
| Rushing Yards | 108.4 yards/game |
| Turnovers | 0.2/game |
Seattle got the job done in a 13-10 defensive grind against New England in Week 1, but losing Darnold for a few weeks throws a wrench in their rhythm. What I like about this team is how Drew Lock stepped up under pressure without throwing away the football.
Defensively, Seattle is taking care of business and stepping up when injuries strike. With safety Ty Okada sidelined, Rodney Thomas II filled in seamlessly, recording a crucial pass breakup that turned into an interception alongside an open-field tackle. The Seahawks are averaging around 312 total yards per game and holding opponents check, keeping turnovers down to an impressive 0.2 per contest. They have plenty of names on the injury report, including Zach Charbonnet on PUP, but their defense knows how to protect a thin lead.
Arizona Cardinals – Team Analysis
| Date | Stage | Opponent | Score | Result |
|---|---|---|---|---|
| 2026-09-13 | Regular Season | @ Los Angeles Chargers | 26-14 | W |
| 2026-08-29 | Pre Season | @ Green Bay Packers | 38-42 | L |
| 2026-08-23 | Pre Season | vs Dallas Cowboys | 13-34 | L |
| 2026-08-14 | Pre Season | @ Las Vegas Raiders | 27-14 | W |
| 2026-08-07 | Pre Season | vs Carolina Panthers | 30-33 | L |
| Stat | Value |
|---|---|
| Avg Points Scored | 26.8 pts/game |
| Avg Points Conceded | 27.4 pts/game |
| Current Form | WLLWL |
| Total Yards | 351.0 yards/game |
| Passing Yards | 244.0 yards/game |
| Rushing Yards | 107.0 yards/game |
| Turnovers | 1.0/game |
Jacoby Brissett looks completely comfortable in this offense, mostly because he has the exact same wide receiver and tight end group surrounding him for the second straight year. That chemistry showed up immediately in their 26-14 victory over Los Angeles, pushing Arizona’s total offense to around 351 yards per game with 244 of those coming through the air. However, those numbers come with a catch. They average a full turnover per game and dropped a chaotic 42-38 shootout against Green Bay recently. Can LaFleur keep this unit dialed in on the road?
The backfield injuries worry me though. Losing both James Conner and Trey Benson to I.L. strips away vital rushing depth and puts way too much pressure on Brissett’s shoulders.
Head-to-Head Record
| Date | Stage | Match | Score | Winner |
|---|---|---|---|---|
| 2025-11-09 | Regular Season | Seattle Seahawks vs Arizona Cardinals | 44-22 | Seattle Seahawks |
| 2025-09-26 | Regular Season | Arizona Cardinals vs Seattle Seahawks | 20-23 | Seattle Seahawks |
| 2024-12-08 | Regular Season | Arizona Cardinals vs Seattle Seahawks | 18-30 | Seattle Seahawks |
| 2024-11-24 | Regular Season | Seattle Seahawks vs Arizona Cardinals | 16-6 | Seattle Seahawks |
| 2024-01-07 | Regular Season | Arizona Cardinals vs Seattle Seahawks | 20-21 | Seattle Seahawks |
| Team | Wins |
|---|---|
| Seattle Seahawks | 5 |
| Draws | 0 |
| Arizona Cardinals | 0 |
If you look at the recent history, Seattle has completely dominated this series. The Seahawks have won five straight against Arizona, including a 44-22 blowout and a tight 23-20 finish in 2025. That kind of track record usually gives a team massive confidence, but with Lock under center instead of Darnold, past results won’t hand Seattle an easy victory.
Team News & Key Players
Seattle Seahawks – Key Players
No player statistics available for Seattle Seahawks this season.
Arizona Cardinals – Key Players
No player statistics available for Arizona Cardinals this season.
Injury Report
Seattle Seahawks:
| Player | Status | Injury | Details |
|---|---|---|---|
| Ty Okada | Questionable | Hamstring – Questionable for Week 2 at Arizona | |
| Tory Horton | Questionable | Hamstring – Questionable for Week 2 at Arizona | |
| Sam Darnold | Questionable | Lower Body – Questionable for Week 2 at Arizona | |
| Nick Emmanwori | Questionable | Ankle – Questionable for Week 2 at Arizona | |
| Zach Charbonnet | PUP | Knee – ACL – Physically Unable to Perform. Expected Return – Week 5 | |
| Mason Richman | I.L. | I.L. – Leg | |
| Bud Clark | I.L. | I.L. – Ankle | |
| Jake Bobo | I.L. | I.L. – Knee | |
| Robbie Ouzts | I.L. | I.L. – Neck |
Arizona Cardinals:
| Player | Status | Injury | Details |
|---|---|---|---|
| Dadrion TaylorDemerson | Questionable | Ribs – Questionable for Week 2 vs. Seattle | |
| Isaiah Adams | Questionable | Knee – Questionable for Week 2 vs. Seattle | |
| Garrett Williams | Questionable | Achilles – Questionable for Week 2 vs. Seattle | |
| Kitan Crawford | Questionable | Ankle – Questionable for Week 2 vs. Seattle | |
| James Conner | I.L. | I.L. – Foot | |
| Zach Carter | I.L. | I.L. – Knee | |
| Trey Benson | I.L. | I.L. – Knee | |
| Tip Reiman | PUP | Ankle – Physically Unable to Perform. Expected Return – Week 5 | |
| Chase Bisontis | I.L. | I.L. – Knee – MCL | |
| Jameson Geers | I.L. | I.L. – Undisclosed | |
| Joey Blount | Questionable | Undisclosed – Questionable for Week 1 at L.A. Chargers | |
| Kaleb Proctor | I.L. | I.L. – Knee – Meniscus |
Darnold’s glute injury is the biggest storyline here, forcing Seattle to trust Drew Lock under center. For Arizona, losing James Conner and Trey Benson to I.L. severely limits what they can do on the ground.
Betting Analysis & Tips
| Market | Selection | Odds |
|---|---|---|
| Moneyline | Seattle Seahawks | 1.46 |
| Moneyline | Arizona Cardinals | 2.52 |
| Total | Over/Under | 41.0 |
Seattle sits as a 1.46 favorite on the board, but my gut says Arizona keeps this competitive with Brissett throwing to familiar targets. The total line rests at 41.0, and considering Seattle’s low turnover rate and Arizona’s thin running back room, I see real value in the under. While our analysis leans heavily toward Seattle, expect Arizona to push them much harder than the 5% win probability suggests.
Final Prediction
I’m taking Seattle to pull this out at home because Drew Lock proved he can manage the game without making critical mistakes. It makes me a little nervous knowing Darnold is out, but Seattle’s defense should do just enough to squeeze out a win. Give me Seattle in a gritty divisional matchup.
| Predicted Score | Seattle Seahawks 21 – 21 Arizona Cardinals |
| Most Likely Result | Seattle Seahawks Win |
Responsible Gambling
This prediction is for entertainment purposes only. Past performance does not guarantee future results. Please gamble responsibly. If you feel you may have a gambling problem, seek help at www.begambleaware.org.
NBA & NFL Expert
